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Article

Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer.

International journal of cancer - 15 Nov 2013

Tuhkanen Hanna, Hartikainen Jaana M, Soini Ylermi, Velasco Gloria, Sironen Reijo, Nykopp Timo K, Kataja Vesa, Eskelinen Matti, Kosma Veli-Matti, Mannermaa Arto

Abstract excerpt

Matriptase-2 (TMPRSS6) has been identified as a breast cancer risk factor. Here, we examined relationships between TMPRSS6 genetic variations and breast cancer risk and survival, and determined the gene and protein expressions in breast tumors and assessed their clinical importance. Thirteen TMPRSS6 polymorphisms were genotyped in 462 invasive breast cancer cases and 458 controls. Gene expression was analyzed...

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Source

Identifiers

PMID: 23649491
DOI: 10.1002/ijc.28254

Genes

TMPRSS6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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