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Article

Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics.

Nature - 23 May 2013

Ho Chin Yee, Jaalouk Diana E, Vartiainen Maria K, Lammerding Jan

Abstract excerpt

Laminopathies, caused by mutations in the LMNA gene encoding the nuclear envelope proteins lamins A and C, represent a diverse group of diseases that include Emery-Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy (DCM), limb-girdle muscular dystrophy, and Hutchison-Gilford progeria syndrome. Most LMNA mutations affect skeletal and cardiac muscle by mechanisms that remain incompletely understood. Loss of...

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Source

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Identifiers

PMID: 23644458
DOI: 10.1038/nature12105
PMCID: PMC3666313

Genes

LMNA
SRF

Provenance

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From gene to mechanics: a comprehensive insight into the mechanobiology of LMNA mutations in cardiomyopathy.Semantic proximity Read ↗

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