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Article

CD8A gene polymorphisms predict severity factors in chronic rhinosinusitis.

International forum of allergy & rhinology - 1 Aug 2013

Alromaih Saud, Mfuna-Endam Leandra, Bosse Yohan, Filali-Mouhim Abdelali, Desrosiers Martin

Abstract excerpt

BACKGROUND: A genetic basis to chronic rhinosinusitis (CRS) is postulated, but remains elusive. We have recently identified low levels of circulating CD8 lymphocytes as a frequent finding in difficult-to-treat or refractory CRS. In major histocompatibility complex 1 class 1 (MHC1) deficiency, low circulating levels of CD8 lymphocytes secondary to mutations in the cluster of differentiation 8a (CD8A), tapasin 1...

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Source

Identifiers

PMID: 23640800
DOI: 10.1002/alr.21174

Genes

TAPBP
TAP1
TAP2

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