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Article

Polymorphisms in the SERPINA1 (Alpha-1-Antitrypsin) gene are associated with severe chronic rhinosinusitis unresponsive to medical therapy.

American journal of rhinology & allergy - 1 Jan 2000

Kilty Shaun J, Bossé Yohan, Cormier Chantale, Endam Leandra Mfuna, Desrosiers Martin Y

Abstract excerpt

BACKGROUND: Alpha-1-antitrypsin (AAT) is a serine protease inhibitor that blocks the protease, neutrophil elastase. Previous population studies have suggested that heterozygote status for the AAT gene (SERPINA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). This impli...

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Source

Identifiers

PMID: 20109307
DOI: 10.2500/ajra.2010.24.3429

Genes

SERPINA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20109307-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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