Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome.

doi:10.1158/1940-6207.CAPR-13-0020

Article

Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome.

Cancer prevention research (Philadelphia, Pa.) - 1 Aug 2013

Lu Karen H, Loose David S, Yates Melinda S, Nogueras-Gonzalez Graciela M, Munsell Mark F, Chen Lee-May, Lynch Henry, Cornelison Terri, Boyd-Rogers Stephanie, Rubin Mary, Daniels Molly S, Conrad Peggy, Milbourne Andrea, Gershenson David M, Broaddus Russell R

Abstract excerpt

Women with Lynch syndrome have a 40% to 60% lifetime risk for developing endometrial cancer, a cancer associated with estrogen imbalance. The molecular basis for endometrial-specific tumorigenesis is unclear. Progestins inhibit estrogen-driven proliferation, and epidemiologic studies have shown t...

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