Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations.

doi:10.1093/cvr/cvt106

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Article

Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations.

Cardiovascular research - 1 Aug 2013

Arimura Takuro, Onoue Kenji, Takahashi-Tanaka Yumiko, Ishikawa Taisuke, Kuwahara Masayoshi, Setou Mitsutoshi, Shigenobu Shuji, Yamaguchi Katsushi, Bertrand Anne T, Machida Noboru, Takayama Kazumi, Fukusato Masayuki, Tanaka Ryo, Somekawa Satoshi, Nakano Tomoya, Yamane Yoshihisa, Kuba Keiji, Imai Yumiko, Saito Yoshihiko, Bonne Gisèle, Kimura Akinori

Abstract excerpt

AIMS: Dilated cardiomyopathy (DCM) is characterized by ventricular dilation associated with systolic dysfunction, which could be caused by mutations in lamina/C gene (LMNA). LMNA-linked DCM is severe in males in both human patients and a knock-in mouse model carrying a homozygous p.H222P mutation (LmnaH222P/H222P). The aim of this study was to investigate the molecular mechanisms underlying the gender difference...

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PMID: 23631840
DOI: 10.1093/cvr/cvt106

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LMNA

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