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Article

Polymorphisms in double-strand breaks repair genes are associated with impaired fertility in Chinese population.

Reproduction (Cambridge, England) - 1 May 2013

Ji Guixiang, Yan Lifeng, Liu Wei, Huang Cong, Gu Aihua, Wang Xinru

Abstract excerpt

The DNA double-strand breaks (DSBs) repair pathway plays a critical role in repairing double-strand breaks, and genetic variants in DSBs repair pathway genes are potential risk factors for various diseases. To test the hypothesis that polymorphisms in DSBs genes are associated with susceptibility to male infertility, we examined 11 single nucleotide polymorphisms in eight key DSBs genes (XRCC3, XRCC2, BRCA2,...

Read the complete abstract on PubMed

Topics

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Share to DNA Breaks, Double-Stranded
Share to DNA Fragmentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Ligase ATP

Share to DNA Ligases

Share to In Situ Nick-End Labeling

Share to Infertility, Male

Share to Oligospermia

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Source

Identifiers

PMID: 23630330
DOI: 10.1530/REP-12-0370

Genes

LIG4
RAG1
ATM
BRCA2
XRCC2
XRCC3
XRCC4
XRCC5

Variants

rs2227973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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