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Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population.

Free radical biology & medicine - 15 Feb 2012

Ji Guixiang, Gu Aihua, Wang Yubang, Huang Cong, Hu Fan, Zhou Yong, Song Ling, Wang Xinru

Abstract excerpt

To test the hypothesis that polymorphisms in antioxidant genes are more susceptible to sperm DNA damage and male infertility, we examined 11 single-nucleotide polymorphisms from six antioxidant genes (GPX1, CAT, PON1, NQO1, SOD2/MnSOD, and SOD3) in 580 infertility cases and 580 controls from a Chinese population-based case-control study (NJMU Infertility Study). Genotypes were determined using the OpenArray...

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Source

Identifiers

PMID: 22206979
DOI: 10.1016/j.freeradbiomed.2011.11.032

Genes

PON1
SOD2
CAT
GPX1
NQO1
SOD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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