SOD1 and SOD2 gene variants are significantly correlated with male infertility in a North Indian population, suggesting a possible pleiotropic conflict.

Abstract excerpt

CONTEXT: Oxidative stress has a detrimental effect on sperm quality, which can lead to infertility. Antioxidant enzymes, such as superoxide dismutases (SODs), have crucial role to protect sperms from oxidative stress. Variations in the SOD genes have thus been linked to male fertility. AIMS: The primary aim of the study was to evaluate the genetic factors contributing to male reproductive health in the population...

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• Case-Control Studies
• SOD2 gene
• Genetic Predisposition to Disease
• India
• Infertility, Male