Article
Nebulin binding impedes mutant desmin filament assembly.
Molecular biology of the cell - 1 Jun 2013
Baker Laura K, Gillis David C, Sharma Sarika, Ambrus Andy, Herrmann Harald, Conover Gloria M
Abstract excerpt
Desmin intermediate filaments (DIFs) form an intricate meshwork that organizes myofibers within striated muscle cells. The mechanisms that regulate the association of desmin to sarcomeres and their role in desminopathy are incompletely understood. Here we compare the effect nebulin binding has on the assembly kinetics of desmin and three desminopathy-causing mutant desmin variants carrying mutations in the head,...
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