Article
Nebulette is a powerful cytolinker organizing desmin and actin in mouse hearts.
Molecular biology of the cell - 1 Dec 2016
Hernandez Daniel A, Bennett Christina M, Dunina-Barkovskaya Lyubov, Wedig Tatjana, Capetanaki Yassemi, Herrmann Harald, Conover Gloria M
Abstract excerpt
In the hearts of patients bearing nebulette mutations, a severe general disorganization in cardiomyocytes of the extrasarcomeric desmin intermediate filament system is frequently observed. However, the molecular and functional relationship between the desmin cytoskeleton and nebulette-containing sarcomeres is still unclear. Here we report a high-affinity in vitro interaction between nebulette and desmin...
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