Article
The mismatch repair gene hPMS1 (human postmeiotic segregation1) is down regulated in oral squamous cell carcinoma.
Gene - 15 Jul 2013
Wang Yimin, Zhou Xuanbo, Song Yang, Ji Xiaofeng, Zhang Aichen, Zhang Guizhen, Gao Zhongli
Abstract excerpt
Genomic instability or microsatellite instability (MSI) was initially recognized in colonic carcinoma and subsequently in other tumors. MSI has been associated with mutations in genes that play a role in DNA replication and repair. In a previous study we detected MSI in 85% of young patients with OSCC and excluded the involvement of MMR genes hMLH1 and hMSH2. In the present study, we screened the mutation and...
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