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Article

Autophagy Fails to Alter Withaferin A-Mediated Lethality in Human Breast Cancer Cells

1 Jun 2013

Abstract excerpt

We have shown previously that withaferin A (WA), which is a highly promising anticancer constituent of Ayurvedic medicine plant Withania somnifera, inhibits viability of cultured breast cancer cells in association with reactive oxygen species (ROS)-dependent apoptosis induction. Because ROS production is implicated in induction of autophagy, which is an evolutionary conserved process for bulk degradation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23607597
DOI: 10.2174/15680096113139990039

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