Sofosbuvir for previously untreated chronic hepatitis C infection.

doi:10.1056/NEJMoa1214853

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Article

Sofosbuvir for previously untreated chronic hepatitis C infection.

The New England journal of medicine - 16 May 2013

Lawitz Eric, Mangia Alessandra, Wyles David, Rodriguez-Torres Maribel, Hassanein Tarek, Gordon Stuart C, Schultz Michael, Davis Mitchell N, Kayali Zeid, Reddy K Rajender, Jacobson Ira M, Kowdley Kris V, Nyberg Lisa, Subramanian G Mani, Hyland Robert H, Arterburn Sarah, Jiang Deyuan, McNally John, Brainard Diana, Symonds William T, McHutchison John G, Sheikh Aasim M, Younossi Zobair, Gane Edward J

Abstract excerpt

BACKGROUND: In phase 2 trials, the nucleotide polymerase inhibitor sofosbuvir was effective in previously untreated patients with chronic hepatitis C virus (HCV) genotype 1, 2, or 3 infection. METHODS: We conducted two phase 3 studies in previously untreated patients with HCV infection. In a single-group, open-label study, we administered a 12-week regimen of sofosbuvir plus peginterferon alfa-2a and ribavirin in...

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PMID: 23607594
DOI: 10.1056/NEJMoa1214853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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