Article
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection.
The New England journal of medicine - 17 Apr 2014
Afdhal Nezam, Reddy K Rajender, Nelson David R, Lawitz Eric, Gordon Stuart C, Schiff Eugene, Nahass Ronald, Ghalib Reem, Gitlin Norman, Herring Robert, Lalezari Jacob, Younes Ziad H, Pockros Paul J, Di Bisceglie Adrian M, Arora Sanjeev, Subramanian G Mani, Zhu Yanni, Dvory-Sobol Hadas, Yang Jenny C, Pang Phillip S, Symonds William T, McHutchison John G, Muir Andrew J, Sulkowski Mark, Kwo Paul
Abstract excerpt
BACKGROUND: Effective treatment for hepatitis C virus (HCV) genotype 1 infection in patients who have not had a sustained virologic response to prior interferon-based therapy represents an unmet medical need. METHODS: We conducted a phase 3, randomized, open-label study involving patients infected with HCV genotype 1 who had not had a sustained virologic response after treatment with peginterferon and ribavirin,...
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