Article
Impaired α-TTP-PIPs interaction underlies familial vitamin E deficiency.
Science (New York, N.Y.) - 31 May 2013
Kono Nozomu, Ohto Umeharu, Hiramatsu Tatsufumi, Urabe Michiko, Uchida Yasunori, Satow Yoshinori, Arai Hiroyuki
Abstract excerpt
α-Tocopherol (vitamin E) transfer protein (α-TTP) regulates the secretion of α-tocopherol from liver cells. Missense mutations of some arginine residues at the surface of α-TTP cause severe vitamin E deficiency in humans, but the role of these residues is unclear. Here, we found that wild-type α-TTP bound phosphatidylinositol phosphates (PIPs), whereas the arginine mutants did not. In addition, PIPs in the target...
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