Rotavirus Replication: Gaps of Knowledge on Virus Entry and Morphogenesis

doi:10.1620/tjem.248.285

Article

Rotavirus Replication: Gaps of Knowledge on Virus Entry and Morphogenesis

1 Jan 2019

Abstract excerpt

In 1973, rotaviruses A (RVAs) were discovered as major causative agents of acute gastroenteritis in infants and young children worldwide. The infectious RV virion is an icosahedral particle composed of three concentric protein layers surrounding the 11 double-stranded (dsRNA) segments. An in vitro replication system for RVs in permanent cell lines was developed in 1982 and expanded to replication in intestinal...

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