Article
Transplanted murine long-term repopulating hematopoietic cells can differentiate to osteoblasts in the marrow stem cell niche.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Jun 2013
Hofmann Ted J, Otsuru Satoru, Marino Roberta, Rasini Valeria, Veronesi Elena, Murgia Alba, Lahti Jill, Boyd Kelli, Dominici Massimo, Horwitz Edwin M
Abstract excerpt
Bone marrow transplantation (BMT) can give rise to donor-derived osteopoiesis in mice and humans; however, the source of this activity, whether a primitive osteoprogenitor or a transplantable marrow cell with dual hematopoietic and osteogenic potential, has eluded detection. To address this issue, we fractionated whole BM from mice according to cell surface immunophenotype and assayed the hematopoietic and...
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