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Article

Zinc deficiency regulates hippocampal gene expression and impairs neuronal differentiation

16 Jan 2013

Abstract excerpt

OBJECTIVES: Proliferating adult stem cells in the subgranular zone of the dentate gyrus have the capacity not only to divide, but also to differentiate into neurons and integrate into the hippocampal circuitry. The present study identifies several hippocampal genes putatively regulated by zinc and tests the hypothesis that zinc deficiency impairs neuronal stem cell differentiation. METHODS: Genes that regulate...

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PMID: 23582512
DOI: 10.1179/1476830512y.0000000043

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