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Article

Association of dopamine-related genetic loci to dopamine D3 receptor antagonist ABT-925 clinical response.

Translational psychiatry - 9 Apr 2013

Bhathena A, Wang Y, Kraft J B, Idler K B, Abel S J, Holley-Shanks R R, Robieson W Z, Spear B, Redden L, Katz D A

Abstract excerpt

ABT-925, a selective dopamine D3 receptor (DRD3) antagonist, was tested in schizophrenia. A DRD3 gene polymorphism results in an S9G amino-acid change that has been associated with lower risk of schizophrenia, higher affinity for dopamine and some antipsychotics, and differential response to some antipsychotics. The effect of S9G genotype on response to ABT-925 was examined. DNA samples (N=117) were collected in...

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Source

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Identifiers

PMID: 23571810
DOI: 10.1038/tp.2013.22
PMCID: PMC3641409

Genes

DRD3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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