Article
Evidence of new risk genetic factor to systemic lupus erythematosus: the UBASH3A gene.
PloS one - 1 Jan 2013
Diaz-Gallo Lina-Marcela, Sánchez Elena, Ortego-Centeno Norberto, Sabio Jose Mario, García-Hernández Francisco J, de Ramón Enrique, González-Gay Miguel A, Torsten Witte, Anders Hans-Joachim, González-Escribano María F, Martin Javier
Abstract excerpt
The ubiquitin associated and Src-homology 3 (SH3) domain containing A (UBASH3a) is a suppressor of T-cell receptor signaling, underscoring antigen presentation to T-cells as a critical shared mechanism of diseases pathogenesis. The aim of the present study was to determine whether the UBASH3a gene influence the susceptibility to systemic lupus erythematosus (SLE) in Caucasian populations. We evaluated five...
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