Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sterile Alpha Motif Containing 7 (Samd7) Is a Novel Crx-Regulated Transcriptional Repressor in the Retina

2 Apr 2013

Abstract excerpt

Inherited retinal diseases are mainly caused by mutations in genes that are highly expressed in photoreceptors of the retina. The majority of these genes is under the control of the transcription factor Cone rod homeobox (Crx), that acts as a master transcription factor in photoreceptors. Using a genome-wide chromatin immunoprecipitation dataset that highlights all potential in vivo targets of Crx, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ocular Disorders and Treatments
Share to Ocular Oncology and Treatments
Share to Retinal Development and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23565263
DOI: 10.1371/journal.pone.0060633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sterile Alpha Motif Containing 7 (Samd7) Is a Novel Crx-Regulated Transcriptional Repressor in the RetinaPMID 23565263Read ↗

Mutations in SAMD7 cause autosomal-recessive macular dystrophy with or without cone dysfunction.Semantic proximity Read ↗

Identification of the Photoreceptor Transcriptional Co-Repressor SAMD11 as Novel Cause of Autosomal Recessive Retinitis Pigmentosa.Semantic proximity Read ↗

Autosomal recessive retinitis pigmentosa with homozygous rhodopsin mutation E150K and non-coding cis-regulatory variants in CRX-binding regions of SAMD7Semantic proximity Read ↗

CRX directs photoreceptor differentiation by accelerating chromatin remodeling at specific target sitesSemantic proximity Read ↗

Pathogenic variants in Crx have distinct cis-regulatory effects on enhancers and silencers in photoreceptorsSemantic proximity Read ↗

Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor developmentSemantic proximity Read ↗

Transcriptional precision in photoreceptor development and diseases – Lessons from 25 years of CRX researchSemantic proximity Read ↗

Multi-omics approach dissects cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathySemantic proximity Read ↗

The Atoh7 remote enhancer provides transcriptional robustness during retinal ganglion cell developmentSemantic proximity Read ↗

Enhancer transcription identifies <i>cis</i> -regulatory elements for photoreceptor cell typesSemantic proximity Read ↗

<i>Myelin regulatory factor</i> ( <i>Myrf</i> ) is a critical early regulator of retinal pigment epithelial developmentSemantic proximity Read ↗

The master transcription factor SOX2, mutated in anophthalmia/microphthalmia, is post-transcriptionally regulated by the conserved RNA-binding protein RBM24 in vertebrate eye development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.