Article
Relationship between nicotine dependence and the endophenotype-related trait of cognitive function but not acoustic startle reponses in Japanese patients with schizophrenia.
Human psychopharmacology - 1 May 2013
Kishi Taro, Fukuo Yasuhisa, Okochi Tomo, Kawashima Kunihiro, Moriwaki Masatsugu, Furukawa Osamu, Musso Giovanna M, Fujita Kiyoshi, Correll Christoph U, Iwata Nakao
Abstract excerpt
OBJECTIVES: We investigated whether nicotine dependence affects these endophenotypes in Japanese schizophrenia patients and whether alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (alpha4 subunit of the nAChR gene (CHRNA4)/beta2 subunit of the nAChR gene (CHRNB2)) were associated with nicotine dependence in patients (n = 100) and healthy controls (n = 107). METHODS: First, in...
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