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Article

A mitochondrial bioenergetic etiology of disease.

The Journal of clinical investigation - 1 Apr 2013

Wallace Douglas C

Abstract excerpt

The classical Mendelian genetic perspective has failed to adequately explain the biology and genetics of common metabolic and degenerative diseases. This is because these diseases are primarily systemic bioenergetic diseases, and the most important energy genes are located in the cytoplasmic mitochondrial DNA (mtDNA). Therefore, to understand these "complex" diseases, we must investigate their bioenergetic...

Topics

Animals
DNA, Mitochondrial
Energy Metabolism
Epigenesis, Genetic
Genetic Predisposition to Disease
Genome, Mitochondrial
Human Migration
Humans
Metabolic Diseases
Mutation
Neuromuscular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23543062
DOI: 10.1172/JCI61398
PMCID: PMC3614529

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