Article
No clinically significant drug-resistance mutations in HIV-1 subtype C-infected women after discontinuation of NRTI-based or PI-based HAART for PMTCT in Botswana.
Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2013
Souda Sajini, Gaseitsiwe Simani, Georgette Nathan, Powis Kathleen, Moremedi Daisy, Iketleng Thato, Leidner Jean, Moffat Claire, Ogwu Anthony, Lockman Shahin, Moyo Sikhulile, Mmalane Mompati, Musonda Rosemary, Makhema Joseph, Essex Max, Shapiro Roger
Abstract excerpt
Risk of developing drug resistance after stopping antiretroviral regimens to prevent mother-to-child HIV-1 transmission is unknown. The Mma Bana Study randomized treatment-naive pregnant women with CD4 ≥200 cells per cubic millimeter to receive either abacavir/zidovudine/lamivudine [triple nucleoside reverse transcriptase inhibitor (NRTI) arm] or lopinavir/ritonavir/zidovudine/lamivudine [protease inhibitor (PI)...
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