Article
Fibrous dysplasia and fibroblast growth factor-23 regulation.
Current osteoporosis reports - 1 Jun 2013
Boyce Alison M, Bhattacharyya Nisan, Collins Michael T
Abstract excerpt
Fibrous dysplasia (FD) is a skeletal disorder caused by activating mutations in Gsα that result in elevations in cAMP. A feature of FD is elevated blood levels of the bone cell-derived phosphaturic hormone, fibroblast growth factor-23 (FGF23). FGF23 regulates serum phosphorus and active vitamin D levels by action on proximal renal tubule cells. An essential step in the production of biologically active FGF23 is...
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