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Article

Mechanistic insights into mutations that cause diseases of phosphate dysregulation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2026

Zhang Liping, Lee Alisa E, Tian E, Collins Michael T, Roszko Kelly L, Samara Nadine L, Ten Hagen Kelly G

Abstract excerpt

Phosphate plays essential roles within the human body and levels are tightly controlled through conserved feedback loops. FGF23, a phosphate-regulating hormone produced in the bone, is regulated by the glycosyltransferase, GALNT3, whose expression is sensitive to circulating phosphate levels. GALNT3-mediated glycosylation of FGF23 confers protection from inactivating furin cleavage, thus allowing intact FGF23 to...

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Share to Fibroblast Growth Factor-23
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to N-Acetylgalactosaminyltransferases

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Share to Polypeptide N-acetylgalactosaminyltransferase

Source

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Identifiers

PMID: 42555639
DOI: 10.1073/pnas.2603453123
PMCID: PMC13462579

Genes

FGF23
GALNT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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