Article
Resolving cell lineage contributions to the ventricular conduction system with a Cx40-GFP allele: a dual contribution of the first and second heart fields.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Jun 2013
Miquerol Lucile, Bellon Anaïs, Moreno Natividad, Beyer Sabrina, Meilhac Sigolène M, Buckingham Margaret, Franco Diego, Kelly Robert G
Abstract excerpt
BACKGROUND: The ventricular conduction system (VCS) coordinates the heartbeat and is composed of central components (the atrioventricular node, bundle, and right and left bundle branches) and a peripheral Purkinje fiber network. Conductive myocytes develop from common progenitor cells with working myocytes in a bimodal process of lineage restriction followed by limited outgrowth. The lineage relationship between...
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