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Article

Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase.

Biochimie - 1 Jul 2013

Kálmán Fanni S, Lizák Beáta, Nagy Szilvia K, Mészáros Tamás, Zámbó Veronika, Mandl József, Csala Miklós, Kereszturi Eva

Abstract excerpt

NADH cytochrome b5 oxidoreductase (Ncb5or) protects β-cells against oxidative stress and lipotoxicity. The predominant phenotype of lean Ncb5or-null mouse is insulin-dependent diabetes due to β-cell death. This suggests the putative role of NCB5OR polymorphism in human diabetes. Therefore, we aim...

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Identifiers

PMID: 23523930
DOI: 10.1016/j.biochi.2013.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23523930-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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