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Article

Quantifying the effect of covariates on concentrations and effects of steady-state phenprocoumon using a population pharmacokinetic/pharmacodynamic model.

Clinical pharmacokinetics - 1 May 2013

Abduljalil Khaled, Lazar Simone, Natanzon Michael, Wu Weidong, Zadoyan Gregor, Steffens Benedict, Kohl Victoria, Mörike Klaus, Tomalik-Scharte Dorota, Stingl Julia, Schwab Matthias, Harenberg Job, Gleiter Christoph, Fuhr Uwe

Abstract excerpt

BACKGROUND AND OBJECTIVES: The oral anticoagulant phenprocoumon, similar to other vitamin K antagonists, is characterized by pronounced interindividual variability in the doses needed to achieve the desired therapeutic effect. Previous studies assessed the effect of genetic and demographic covariates on empirical dose requirements of phenprocoumon to enable individualized dose prediction. The aim of the present...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23519598
DOI: 10.1007/s40262-013-0043-z

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Quantifying the effect of covariates on concentrations and effects of steady-state phenprocoumon using a population pharmacokinetic/pharmacodynamic model.PMID 23519598Read ↗

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