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Article

Loading and maintenance dose algorithms for phenprocoumon and acenocoumarol using patient characteristics and pharmacogenetic data.

European heart journal - 1 Aug 2011

van Schie Rianne M F, Wessels Judith A M, le Cessie Saskia, de Boer Anthonius, Schalekamp Tom, van der Meer Felix J M, Verhoef Talitha I, van Meegen Erik, Rosendaal Frits R, Maitland-van der Zee Anke-Hilse

Abstract excerpt

AIMS: Polymorphisms in CYP2C9 and VKORC1 influence patients' phenprocoumon (PHE) and acenocoumarol (ACE) dose requirements. To provide physicians with tools to estimate the patient's individual dose, we aimed to develop algorithms for PHE and ACE. METHODS AND RESULTS: In two Dutch anticoagulation clinics, data on age, sex, height, weight, co-medication, coumarin derivative doses, and international normalized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21636598
DOI: 10.1093/eurheartj/ehr116

Genes

ACE
VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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