Article
Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1.
FEBS letters - 21 May 2013
Baglivo Ilaria, Esposito Sabrina, De Cesare Lucia, Sparago Angela, Anvar Zahra, Riso Vincenzo, Cammisa Marco, Fattorusso Roberto, Grimaldi Giovanna, Riccio Andrea, Pedone Paolo V
Abstract excerpt
In the mouse, ZFP57 contains three classical Cys2His2 zinc finger domains (ZF) and recognizes the methylated TGC(met)CGC target sequence using the first and the second ZFs. In this study, we demonstrate that the human ZFP57 (hZFP57) containing six Cys2His2 ZFs, binds the same methylated sequence...
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