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Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer's disease in CRND8 mice.

Analytical and bioanalytical chemistry - 1 Jun 2013

Lin Shuhai, Liu Hongde, Kanawati Basem, Liu Liangfeng, Dong Jiyang, Li Min, Huang Jiandong, Schmitt-Kopplin Philippe, Cai Zongwei

Abstract excerpt

In the wake of genomics, metabolomics characterizes the small molecular metabolites revealing the phenotypes induced by gene mutants. To address the metabolic signatures in the hippocampus of the amyloid-beta (Aβ) peptides produced in transgenic (Tg) CRND8 mice, high-field ion cyclotron resonance-Fourier transform mass spectrometry supported by LC-LTQ-Orbitrap was introduced to profile the extracted metabolites....

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PMID: 23494273
DOI: 10.1007/s00216-013-6825-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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