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Article

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus.

Viruses - 27 Apr 2018

Mutso Margit, Morro Ainhoa Moliner, Smedberg Cecilia, Kasvandik Sergo, Aquilimeba Muriel, Teppor Mona, Tarve Liisi, Lulla Aleksei, Lulla Valeria, Saul Sirle, Thaa Bastian, McInerney Gerald M, Merits Andres, Varjak Margus

Abstract excerpt

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with numerous host proteins and some crucial interactions are mediated by the unstructured C-terminal hypervariable domain...

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Source

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Identifiers

PMID: 29702546
DOI: 10.3390/v10050226
PMCID: PMC5977219

Genes

CAPZA1
CAPZA2
CAPZB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus.PMID 29702546Read ↗

Structural characterization and biological function of bivalent binding of CD2AP to intrinsically disordered domain of chikungunya virus nsP3 proteinSemantic proximity Read ↗

NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.Semantic proximity Read ↗

NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylationSemantic proximity Read ↗

Multiple Host Factors Interact with the Hypervariable Domain of Chikungunya Virus nsP3 and Determine Viral Replication in Cell-Specific ModeSemantic proximity Read ↗

Interactions of Alphavirus nsP3 Protein with Host ProteinsSemantic proximity Read ↗

Phosphorylation Sites in the Hypervariable Domain in Chikungunya Virus nsP3 Are Crucial for Viral ReplicationSemantic proximity Read ↗

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Structural and Functional Characterization of Host FHL1 Protein Interaction with Hypervariable Domain of Chikungunya Virus nsP3 ProteinSemantic proximity Read ↗

Decoding chikungunya virus non-structural protein 3 interacting partners in THP-1 derived infected macrophages through proteomic profilingSemantic proximity Read ↗

Proteomic Analysis of CHIKV-nsP3 Host Interactions in Liver Cells Identifies Novel Interacting PartnersSemantic proximity Read ↗

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