Article
Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic population.
PloS one - 1 Jan 2013
Zain Shamsul Mohd, Mohamed Zahurin, Mahadeva Sanjiv, Rampal Sanjay, Basu Roma Choudhury, Cheah Phaik-Leng, Salim Agus, Mohamed Rosmawati
Abstract excerpt
Angiotensin II type 1 receptor (AGTR1) has been reported to play a fibrogenic role in non-alcoholic fatty liver disease (NAFLD). In this study, five variants of the AGTR1 gene (rs3772622, rs3772627, rs3772630, rs3772633, and rs2276736) were examined for their association with susceptibility to NAFLD. Subjects made up of 144 biopsy-proven NAFLD patients and 198 controls were genotyped using TaqMan assays. The...