Article
Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.
PloS one - 1 Jan 2013
Nallagatla Subba Rao, Jones Christie N, Ghosh Saikat Kumar B, Sharma Suresh D, Cameron Craig E, Spremulli Linda L, Bevilacqua Philip C
Abstract excerpt
Interferon inducible protein kinase PKR is an essential component of innate immunity. It is activated by long stretches of dsRNA and provides the first line of host defense against pathogens by inhibiting translation initiation in the infected cell. Many cellular and viral transcripts contain nucleoside modifications and/or tertiary structure that could affect PKR activation. We have previously demonstrated that...
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