Article
Metabolic signatures of extreme longevity in northern Italian centenarians reveal a complex remodeling of lipids, amino acids, and gut microbiota metabolism.
PloS one - 1 Jan 2013
Collino Sebastiano, Montoliu Ivan, Martin François-Pierre J, Scherer Max, Mari Daniela, Salvioli Stefano, Bucci Laura, Ostan Rita, Monti Daniela, Biagi Elena, Brigidi Patrizia, Franceschi Claudio, Rezzi Serge
Abstract excerpt
The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort...
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