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Phenotypic upregulation of hexocylceramides and ether-linked phosphocholines as markers of human extreme longevity.

Aging cell - 1 Apr 2025

Fernàndez-Bernal Anna, Sol Joaquim, Galo-Licona José Daniel, Mota-Martorell Natàlia, Mas-Bargues Cristina, Belenguer-Varea Ángel, Obis Èlia, Viña José, Borrás Consuelo, Jové Mariona, Pamplona Reinald

Abstract excerpt

Centenarians and their relatives possess a notable survival advantage, with higher longevity and reduced susceptibility to major age-related diseases. To date, characteristic omics profiles of centenarians have been described, demonstrating that these individuals with exceptional longevity regulate their metabolism to adapt and incorporate more resilient biomolecules into their cells. Among these adaptations, the...

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PMID: 39639682
DOI: 10.1111/acel.14429
PMCID: PMC11984674

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PC

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