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Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells

12 Mar 2013

Abstract excerpt

Human epidermal stem cells express high levels of β1 integrins, delta-like 1 (DLL1) and the EGFR antagonist LRIG1. However, there is cell-to-cell variation in the relative abundance of DLL1 and LRIG1 mRNA transcripts. Single-cell global gene expression profiling showed that undifferentiated cells fell into two clusters delineated by expression of DLL1 and its binding partner syntenin. The DLL1(+) cluster had...

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PMID: 23482486
DOI: 10.1242/dev.087551

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