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Article

A network of genes connects polyglutamine toxicity to ploidy control in yeast.

Nature communications - 1 Jan 2013

Kaiser Christoph J O, Grötzinger Stefan W, Eckl Julia M, Papsdorf Katharina, Jordan Stefan, Richter Klaus

Abstract excerpt

Neurodegeneration is linked to protein aggregation in several human disorders. In Huntington's disease, the length of a polyglutamine stretch in Huntingtin is correlated to neuronal death. Here we utilize a model based on glutamine stretches of 0, 30 or 56 residues in Saccharomyces cerevisiae to understand how such toxic proteins interfere with cellular physiology. A toxicity-mimicking cytostatic effect is...

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PMID: 23481379
DOI: 10.1038/ncomms2575
PMCID: PMC3615466

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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