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Article

Geographical distribution of MTHFR C677T, A1298C and MTRR A66G gene polymorphisms in China: findings from 15357 adults of Han nationality.

PloS one - 1 Jan 2013

Yang Boyi, Liu Yuyan, Li Yongfang, Fan Shujun, Zhi Xueyuan, Lu Xiangxiang, Wang Da, Zheng Quanmei, Wang Yinuo, Wang Yanxun, Sun Guifan

Abstract excerpt

BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms are important genetic determinants for homocysteine (Hcy) levels, and are associated with several disorders. These polymorphisms are heterogeneously distributed worldwide. Our objective was to explore the geographical distributions of these polymorphisms in China. METHODOLOGIES: 15357...

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Identifiers

PMID: 23472119
DOI: 10.1371/journal.pone.0057917
PMCID: PMC3589470

Genes

MTHFR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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