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Article

Fibroblast growth factor receptors-1 and -3 play distinct roles in the regulation of bladder cancer growth and metastasis: implications for therapeutic targeting.

PloS one - 1 Jan 2013

Cheng Tiewei, Roth Beat, Choi Woonyoung, Black Peter C, Dinney Colin, McConkey David J

Abstract excerpt

Fibroblast growth factor receptors (FGFRs) are activated by mutation and overexpressed in bladder cancers (BCs), and FGFR inhibitors are currently being evaluated in clinical trials in BC patients. However, BC cells display marked heterogeneity in their responses to FGFR inhibitors, and the biological mechanisms underlying this heterogeneity are not well defined. Here we used a novel inhibitor of FGFRs 1-3 and...

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Source

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Identifiers

PMID: 23468956
DOI: 10.1371/journal.pone.0057284
PMCID: PMC3582560

Genes

FGFR3
FGFR1
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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