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Article

Polymorphisms of interleukin-1 Beta and interleukin-17Alpha genes are associated with restless legs syndrome.

Biological research for nursing - 1 Apr 2014

Hennessy Mary Dawn, Zak Rochelle S, Gay Caryl L, Pullinger Clive R, Lee Kathryn A, Aouizerat Bradley E

Abstract excerpt

OBJECTIVE: Dopamine, iron, and inflammatory pathways are considered important to the development of restless legs syndrome (RLS). Recent genetic studies support involvement of dopamine and iron; however, cytokine gene variation in the inflammatory component remains unexplored. A recent study reported a high prevalence of RLS among HIV-infected adults. We estimate occurrence of RLS in an ethnically diverse sample...

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Source

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Identifiers

PMID: 23460603
DOI: 10.1177/1099800413478827
PMCID: PMC5697711

Genes

HFE
NOS1
NOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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