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Article

miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis.

British journal of cancer - 19 Mar 2013

McCormick R I, Blick C, Ragoussis J, Schoedel J, Mole D R, Young A C, Selby P J, Banks R E, Harris A L

Abstract excerpt

BACKGROUND: Clear cell renal cancer frequently harbours von Hippel-Lindau (VHL) gene mutations, leading to stabilisation of the hypoxia-inducible factors (HIFs) and expression of their target genes. We investigated HIF-1 and HIF-2 in the regulation of microRNA-210 (miR-210), and its clinical relevance in renal tumours. METHODS: RCC4 and 786-O renal cancer cell lines transfected with either an empty vector or...

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Identifiers

PMID: 23449350
DOI: 10.1038/bjc.2013.56
PMCID: PMC3619073

Genes

VHL
ISCU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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