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Article

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma

27 Apr 2010

Abstract excerpt

BACKGROUND: MicroRNA regulate mRNA levels in a tissue specific way, either by inducing degradation of the transcript or by inhibiting translation or transcription. Putative mRNA targets of microRNA identified from seed sequence matches are available in many databases. However, such matches have a high false positive rate and cannot identify tissue specificity of regulation. RESULTS: We describe a simple method to...

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PMID: 20420713
DOI: 10.1186/1752-0509-4-51

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