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Article

A novel melittin-MhIL-2 fusion protein inhibits the growth of human ovarian cancer SKOV3 cells in vitro and in vivo tumor growth.

Cancer immunology, immunotherapy : CII - 1 May 2013

Liu Mingjun, Zong Jinbao, Liu Zimin, Li Ling, Zheng Xu, Wang Bin, Sun Guirong

Abstract excerpt

In the current study, we produced a novel fusion protein (melittin-mutant human interleukin 2, melittin-MhIL-2) comprising a mutant human interleukin 2 (Arg88/Ala125) genetically linked to melittin. The plasmid pET15b-melittin-MhIL-2 (Arg88/Ala125) was transformed into E. coli for protein expression. The expressed melittin-MhIL-2 protein was purified using a series of purification steps. The interleukin 2 (IL-2)...

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Identifiers

PMID: 23443963
DOI: 10.1007/s00262-013-1401-2
PMCID: PMC11029713

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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