A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy.

doi:10.1371/journal.pone.0056414

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Article

A remote cis-acting variant at 3q links glomerular NCK1 to diabetic nephropathy.

PloS one - 1 Jan 2013

He Bing, Österholm Anne-May, Ojala Juha R M, Andersson Ann-Charlotte, Tryggvason Karl

Abstract excerpt

We have previously reported genetic association of a single nucleotide polymorphism (SNP), rs1866813, at 3q locus with increased risk of diabetic nephropathy (DN). The SNP is located approximately 70 kb downstream of a cluster of four genes. This raises a question how the remote noncoding polymorphism affects the risk of DN. In this study, we tested a long-range regulatory potential of this variant by a series of...

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PMID: 23441190
DOI: 10.1371/journal.pone.0056414
PMCID: PMC3575385

Genes

NCK1

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