Interpreting the role of de novo protein-coding mutations in neuropsychiatric disease.

Abstract excerpt

Pedigree, linkage and association studies are consistent with heritable variation for complex disease due to the segregation of genetic factors in families and in the population. In contrast, de novo mutations make only minor contributions to heritability estimates for complex traits. Nonetheless, some de novo variants are known to be important in disease etiology. The identification of risk-conferring de novo...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autistic Disorder
• Share to Exons
• Share to Genetic Association Studies