Article
Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism.
Genetic counseling (Geneva, Switzerland) - 1 Jan 2012
Avdjieva-Tzavella D M, Todorov T P, Todorova A P, Kirov A V, Hadjidekova S P, Rukova B B, Litvinenko I O, Hristova-Naydenova D N, Tincheva R S, Toncheva D I
Abstract excerpt
Many studies have supported a genetic aetiology for autism. Neuroligins are postsynaptically located cell-adhesion molecules. Mutations in two X-linked neuroligin genes, NLGN3 and NLGN4, have been implicated in pathogenesis of autism. In order to confirm these causative mutations in our autistic population and to determine their frequency we screened 20 individuals affected with autism. We identified one patient...
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