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Article

C5a Receptor Signaling Prevents Folate Deficiency–Induced Neural Tube Defects in Mice

19 Feb 2013

Abstract excerpt

The complement system is involved in a range of diverse developmental processes, including cell survival, growth, differentiation, and regeneration. However, little is known about the role of complement in embryogenesis. In this study, we demonstrate a novel role for the canonical complement 5a receptor (C5aR) in the development of the mammalian neural tube under conditions of maternal dietary folic acid...

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PMID: 23420882
DOI: 10.4049/jimmunol.1203072

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